PeproTech 2019��9�·���Murine C5a��Murine TARC (CCL17)��Murine KGF (FGF-7)��Human 4-1BB Ligand 4����Ʒ��

��Դ�� ����PeproTech(����̩��)��˾�й������   2019-9-3   ��������2440����(0)


ϸ������Murine C5a315-405ug��1,050 
ϸ������Murine C5a315-4020ug��2,570 
ϸ������Murine C5a315-40100ug��9,240 
ϸ������Murine C5a315-40250ug��16,170 
ϸ������Murine C5a315-40500ug��27,720 
ϸ������Murine C5a315-401000ug��46,200 
ϸ������Murine TARC (CCL17)250-435ug��1,050 
ϸ������Murine TARC (CCL17)250-4320ug��2,570 
ϸ������Murine TARC (CCL17)250-43100ug��9,240 
ϸ������Murine TARC (CCL17)250-43250ug��16,170 
ϸ������Murine TARC (CCL17)250-43500ug��27,720 
ϸ������Murine TARC (CCL17)250-431000ug��46,200 
ϸ������Murine KGF (FGF-7)450-602ug��1,050 
ϸ������Murine KGF (FGF-7)450-6010ug��2,570 
ϸ������Murine KGF (FGF-7)450-6050ug��9,600 
ϸ������Murine KGF (FGF-7)450-60100ug��16,010 
ϸ������Murine KGF (FGF-7)450-60250ug��28,020 
ϸ������Murine KGF (FGF-7)450-60500ug��48,040 
ϸ������Murine KGF (FGF-7)450-601000ug��80,080 
�޶���ɷ�ϸ������Human 4-1BB LigandAF-310-115ug��1,250 
�޶���ɷ�ϸ������Human 4-1BB LigandAF-310-1120ug��2,830 
�޶���ɷ�ϸ������Human 4-1BB LigandAF-310-11100ug��10,160 
�޶���ɷ�ϸ������Human 4-1BB LigandAF-310-11250ug��17,780 
�޶���ɷ�ϸ������Human 4-1BB LigandAF-310-11500ug��30,490 
�޶���ɷ�ϸ������Human 4-1BB LigandAF-310-111000ug��50,820 


��Ʒ����:Complement 5a (C5a) is an enzymatically generated glycoprotein belonging to the anaphylatoxin family of structurally and functionally related proteins. Generated upon the activation of the complement system, C5a, together with C4a, C3a, and the membrane attack complex (C5b�\9), functions as a central player in host defense by inducing smooth muscle cell contraction, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes through cell degranulation. In addition to acting as a direct mediator of localized inflammatory response, C5a also initiates both the synthesis and release of IL�\8 from monocytes and bronchial epithelial cells, stimulates the proliferation of neurons and hepatocytes, and functions as a potent chemoattractant. Where C5a deficiency, a rare defect of the complement pathway caused by the mutation of the C5a gene, is associated with susceptibility to severe infections, excessive C5a activation has been linked to liver fibrosis, sepsis, adult respiratory distress syndrome, rheumatoid arthritis, Alzheimer��s disease, and ischemic heart disease. Human C5a shares 60% and 54% sequence identity to mouse and rat C5a, respectively. The human C5 gene encodes a 1,676 amino acid glycoprotein that is comprised of a disulfide�\linked C5 alpha and a C5 beta chain, the former of which contains the active, 74 amino acid C5a anaphylatoxin chain. Recombinant Murine C5a is an 8.9 kDa glycoprotein containing the 77 amino acid residues of the C5a anaphylatoxin chain.

2.������TARC (CCL17)

��Ʒ����:TARC, a CC chemokine, is predominantly produced by dendritic cells in the thymus, and signals through the CCR4 receptor. TARC is chemotactic towards T cells. Recombinant Murine TARC (CCL17) is an 7.9 kDa protein containing 70 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

3.������KGF (FGF-7)

��Ʒ����:KGF (FGF�\7) is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. KGF (FGF�\7) is a mitogen factor specific for epithelial cells and keratinocytes. KGF/FGF�\7 signals through FGFR 2b. KGF (FGF�\7) plays a role in kidney and lung development, as well as in angiogenesis and wound healing. Recombinant Murine KGF (FGF�\7) is an 18.9 kDa protein consisting of 164 amino acid residues.

4.�޶���ɷ�������4-1BB Ligand

��Ʒ����:4�\1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and
macrophages. 4�\1BBL binds to its receptor 4�\1BB, and provides a co�\stimulatory signal for T cell activation and expansion. The human 4�\1BBL gene codes for a 254 amino acid type II transmembrane protein containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane protein domain, and a 205 amino acid extracellular domain. The soluble form of 4�\1BBL contains the TNF�\like portion of the extracellular domain of 4�\1BBL. Recombinant Human 4�\1BB Ligand is a soluble 19.5 kDa protein consisting of 185 amino acid residues.

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